Clinical Applications

• Enhances exercise performance*
• Helps reduce muscle fatigue and supports muscle power, strength, and growth with PEAK ATP*
• Supports post-workout recovery*
• Supports ATP biosynthesis and muscular excitability*
• Provides an alternative to ordinary caffeine*
• Supports electrolyte replacement*
• Provides antioxidant support with S-Acetyl-L-Glutathione and Vitamin C*

FitBoost+ is meticulously crafted to cater to the intensive requirements of the body during and post-exercise routines. This refreshing drink mix offers a combination that's low in carbohydrates and free from sugars, blending bioactive B vitamins, electrolytes, Albion TRAACS® chelated trace minerals, essential amino acids, natural herbs, and robust antioxidants, all without the need for synthetic sweeteners or artificial components. FitBoost+ stands out with its exclusive mix of natural enhancers for exercise, intended to augment muscular excitability, thereby elevating both performance and recovery. Key ingredients in this unique blend include the caffeine/pterostilbene co-crystal, creatine monohydrate, and PEAK ATP® adenosine triphosphate. Opt for FitBoost+ to enhance your workout efficiency and energy utilization.*

Discussion

All-Natural, No Added Sugars

FitBoost+ employs purely natural components instead of relying on ephedra or synthetic energizers to enhance workout efficacy. It boasts a low carbohydrate content with only five grams and absolutely no sugars. Opting for natural flavorings and stevia as alternatives to sugar and other carbs, it sidesteps the common sugar rush found in numerous energy drinks. Additionally, FitBoost+ is free from synthetic colorings.*

PEAK ATP®

Taking ATP (adenosine triphosphate) orally, especially when combined with resistance training, has been observed to yield performance-enhancing results.[1] PEAK ATP, a unique patented version of ATP disodium, is evidenced through human research to boost muscle growth, strength, power, and recovery efficiency. Its effectiveness stems from enhanced muscle excitability, better blood circulation, and amplified anabolic signaling.[1-4] PEAK ATP in FitBoost+ is instrumental in aiding athletes in reaching new heights of performance.*

Studies indicate that a daily intake of 400 mg PEAK ATP can elevate ATP levels post-exercise and augment athletic prowess after multiple sprint cycles. It significantly boosts vasodilation and blood flow post-acute arm exercises.[5,6] Research including a double-blind, placebo-controlled, crossover study demonstrates that 15 days of 400 mg PEAK ATP supplementation “tended to alleviate muscle fatigue and enhanced muscle low-peak torque in exhaustive exercise sets.”[1] Another study involving resistance-trained participants over 12 weeks revealed increased strength (147%), power (30%), lean body mass (100%), and muscle thickness (96%) with PEAK ATP, along with a decrease in body fat compared to the placebo group.[3] These studies also suggest PEAK ATP's role in curtailing performance dips commonly associated with overreaching.[3] Purpura et al. in a randomized, double-blind, placebo-controlled trial (n=42) discovered that two weeks of 400 mg PEAK ATP supplementation prevented declines in ATP and its metabolites caused by exercise, and enhanced peak power and muscle excitability.*[7]

Creatine Monohydrate

Creatine supplementation elevates creatine levels in muscles, boosts energy generation, mitigates muscle tiredness, and diminishes lactic acid production. Notable improvements in body mass, fat-free mass, oxygen uptake, sprint capability, weightlifting performance, and overall exercise capacity have been seen following creatine supplementation.[8-10] In FitBoost+, the synergistic impact of caffeine, creatine, and amino acids has been linked to advancements in time to exhaustion (TTE) and peak velocity (PV) during physical activities.*[11]

Caffeine Pterostilbene Co-Crystal

The caffeine pterostilbene co-crystal is an inventive compound that merges caffeine with pterostilbene, a bioavailable variant of resveratrol, forming a novel co-crystal structure. This structure influences how caffeine is utilized by the body, potentially offering benefits over standard caffeine alone. A rat study (n=6) showed the half-life of caffeine from this co-crystal to be eight hours, compared to only three hours for ordinary caffeine.[12] In a preliminary four-week, single-blind, crossover human study (n=12), 232 mg of caffeine pterostilbene co-crystal (yielding 99.76 mg of caffeine) was compared to 100 mg of ordinary caffeine. The study revealed about 30% slower absorption and 30% more bloodstream caffeine from the co-crystal. Notably, serum caffeine from the co-crystal was 51% higher after six hours compared to ordinary caffeine.*[13,14]

These findings suggest longer-lasting effects of caffeine from the co-crystal than regular caffeine, potentially allowing for reduced overall caffeine consumption. The extended half-life and slower absorption of caffeine from the co-crystal may also lead to a more gradual decline, avoiding the typical crash associated with conventional caffeinated products. While these initial results are encouraging, further extensive studies are required to confirm these benefits and assess if they translate to prolonged energy effects. Interestingly, chlorogenic acids in coffee have been observed to positively impact human fecal microbiota, including Bifidobacterium species, potentially benefiting overall health.*[15]

Herbs and Amino Acids

FitBoost+ combines caffeine pterostilbene co-crystal with various herbs and amino acids, including green tea extract, coffee fruit extract, taurine, and L-arginine alpha-ketoglutarate, in a proprietary blend. This blend is crafted to enhance the functions of caffeine pterostilbene co-crystal. Additionally, when taken in significant doses, some of these individual components are known to contribute to mitochondrial biogenesis and positively affect exercise performance.*[16-18]

Electrolytes and Antioxidants

Electrolytes like sodium, potassium, and magnesium are crucial for energy production, nerve transmission, muscle contractions, pH balance, fluid balance, and more. Excessive sweating and heightened metabolic activity can necessitate the replenishment of these vital minerals and an increased need for antioxidants. FitBoost+ offers 130 mg of sodium, 280 mg of potassium, and 150 mg of magnesium per serving. To aid in combating free radicals, it also provides 500 mg of vitamin C as four mineral ascorbates, along with natural vitamin E, selenium, green tea extract, and s-acetyl-L-glutathione (SAG). SAG is a stable form of glutathione that can penetrate mitochondrial membranes, enhancing mitochondrial function and reducing reactive oxygen species.*

B Vitamins

The B vitamins in FitBoost+ are presented in activated forms to ensure optimal bioavailability and utilization. These water-soluble nutrients serve as vital parts of coenzymes in the complex biochemical processes that convert food into glucose and ATP, the energy currency of cells. Vitamin B12 in particular collaborates with folate in red blood cell production and aids iron in its role of transporting oxygen to all cells, including muscle cells, for energy production.*

References

1. Rathmacher JA, Fuller JC Jr, Baier SM, et al. Adenosine-5’-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets. J Int Soc Sports Nutr. 2012 Oct 9;9(1):48. [PMID: 23046855]
2. Jäger R, Roberts MD, Lowery RP, et al. Oral adenosine-5’-triphosphate (ATP) administration increases blood flow following exercise in animals and humans. J Int Soc Sports Nutr. 2014 Jun 13;11:28. [PMID: 25006331]
3. Wilson JM, Joy JM, Lowery RP, et al. Effects of oral adenosine-5’-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men. Nutr Metab (Lond). 2013 Sep 22;10(1):57. [PMID: 24330670]
4. Kichenin K, Decollogne S, Angignard J, et al. Cardiovascular and pulmonary response to oral administration of ATP in rabbits. J Appl Physiol (1985). 2000 Jun;88(6):1962-8. [PMID: 10846006]
5. Rauch J, Lowery RP, Silva J, et al. The oral bioavailability of ATP following an intense sprinting protocol. In: National Strength and Conditioning Association 2014 Annual Meeting, Las Vegas, NV. J Strength Cond Res. 2014;28(suppl 2):S53-S54. http://journals.lww.com/ nsca-jscr/Fulltext/2014/12001/NSCA_2014_Annual_Meeting.1.aspx. Accessed September 29, 2015.
6. Lowery R, Roberts M, Booth F, et al. Oral ATP administration improves blood flow responses to exercise in both animal and human training models. In: Proceedings of the Tenth International Society of Sports Nutrition (ISSN) Conference and Expo, Colorado Springs, CO. J Int Soc Sports Nutr. 2013;10(suppl 1):P16. http://www.jissn.com/content/10/S1/P16. Accessed September 29, 2015.
7. Purpura M, Rathmacher JA, Sharp MH, et al. Oral adenosine-5’-triphosphate (ATP) administration increases postexercise ATP levels, muscle excitability, and athletic performance following a repeated sprint bout. J Am Coll Nutr. 2017 Jan 12:1-7. [PMID: 28080323]
8. Smith RN, Agharkar AS, Gonzales EB. A review of creatine supplementation in age-related diseases: more than a supplement for athletes. F1000Res. 2014 Sep 15;3:222. [PMID: 25664170]
9. Aguiar AF, Januário RS, Junior RP, et al. Long-term creatine supplementation improves muscular performance during resistance training in older women. Eur J Appl Physiol. 2013 Apr;113(4):987-96. [PMID: 23053133]
10. Bemben MG, Lamont HS. Creatine supplementation and exercise performance: recent findings. Sports Med. 2005;35(2):107-25. [PMID: 15707376]
11. Fukuda DH, Smith AE, Kendall KL, et al. The possible combinatory effects of acute consumption of caffeine, creatine, and amino acids on the improvement of anaerobic running performance in humans. Nutr Res. 2010 Sep;30(9):607-14. [PMID: 20934602]
12. Single-dose comparative pharmacokinetic study of pterostilbene, caffeine and combination of pterostilbene caffeine co-crystal in SD rats by oral route. Study report. Study No: VLL/0912/NG/D033; Version No.: 1.0. Genome Valley, Hyderabad, India: Vimta Labs Limited; November 2012:1-25. [on file]
13. A crossover, clinical evaluation to determine the relative bioavailability, pharmacokinetics and safety of PURENERGY™ and pTeroPure® in healthy adult males. PK study summary. Miami, FL/Irvine, CA: Miami Research Associates/ChromaDex Inc.; 2013:1-34. [on file]
14. Purenergy™: A novel next-generation caffeine alternative. Irvine, CA: ChromaDex Inc.; September 10, 2014:1-5. [on file]
15. Mills CE, Tzounis X, Oruna-Concha MJ, et al. In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human faecal microbiota growth. Br J Nutr. 2015 Apr 28;113(8):1220-27. [PMID: 25809126]
16. Campbell B, Roberts M, Kerksick C, et al. Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men. Nutrition. 2006 Sep;22(9):872-81. [PMID: 16928472]
17. Flôres MF, Martins A, Schimidt HL, et al. Effects of green tea and physical exercise on memory impairments associated with aging. Neurochem Int. 2014 Sep 6. [PMID: 25195719]
18. Pandareesh MD, Anand T. Ergogenic effect of dietary L-carnitine and fat supplementation against exercise induced physical fatigue in Wistar rats. J Physiol Biochem. 2013 Dec;69(4):799-809. [PMID: 23661316]